AWWA WQTC71633

Recent work has shown that polychromatic ultraviolet (UV) sources, such as medium-pressure (MP) UV, are significantly more effective than low-pressure (LP) UV at inactivating adenovirus in cell culture infectivity assays (Eischeid et al., 2009; Linden et al., 2007). It is thought that LP UV primarily damages the viral DNA, and that this damage may be repaired during cell culture infectivity assays, allowing the virus to successfully infect cells and escape inactivation. Such host cell reactivation of the damaged virus does not appear to occur after MP UV irradiation, and this may be because of more widespread, extragenomic damage to the viral particle caused by medium pressure UV. Includes 10 references, figures.